{"id":3158,"date":"2026-02-28T01:52:40","date_gmt":"2026-02-28T01:52:40","guid":{"rendered":"https:\/\/www.bestspinehospitals.com\/blog\/hyperreflexia-definition-uses-and-clinical-overview\/"},"modified":"2026-02-28T01:52:40","modified_gmt":"2026-02-28T01:52:40","slug":"hyperreflexia-definition-uses-and-clinical-overview","status":"publish","type":"post","link":"https:\/\/www.bestspinehospitals.com\/blog\/hyperreflexia-definition-uses-and-clinical-overview\/","title":{"rendered":"Hyperreflexia: Definition, Uses, and Clinical Overview"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Hyperreflexia Introduction (What it is)<\/h2>\n\n\n\n<p>Hyperreflexia means reflexes that are stronger or more easily triggered than expected.<br\/>\nIt is a clinical finding noticed during a neurological exam.<br\/>\nIt most often comes up when clinicians evaluate the brain, spinal cord, and nerve pathways.<br\/>\nIn spine care, it can be a clue to spinal cord involvement, especially in the neck.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why Hyperreflexia is used (Purpose \/ benefits)<\/h2>\n\n\n\n<p>Hyperreflexia is not a treatment or a procedure. It is a sign that helps clinicians interpret how the nervous system is functioning. When a healthcare professional tests reflexes\u2014such as the knee-jerk reflex\u2014they are checking a built-in circuit between a sensory nerve, the spinal cord, and a motor nerve. The strength and pattern of these reflexes can suggest where a problem might be located.<\/p>\n\n\n\n<p>In spine and neuromuscular care, Hyperreflexia is commonly \u201cused\u201d in the sense that it helps with:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Screening for spinal cord involvement (myelopathy):<\/strong> Increased reflexes can occur when the spinal cord\u2019s normal inhibitory control is disrupted, such as with spinal cord compression in the cervical (neck) region.<\/li>\n<li><strong>Localization:<\/strong> Reflex patterns can support a working diagnosis of an <strong>upper motor neuron<\/strong> problem (brain\/spinal cord pathways) versus a <strong>lower motor neuron<\/strong> problem (nerve root\/peripheral nerve).<\/li>\n<li><strong>Prioritizing next steps in evaluation:<\/strong> When Hyperreflexia appears alongside other findings (gait imbalance, hand clumsiness, weakness, sensory changes), it may raise concern for conditions that often require timely assessment.<\/li>\n<li><strong>Tracking change over time:<\/strong> Serial exams can document whether neurological findings are stable, improving, or worsening, though interpretation varies by clinician and case.<\/li>\n<li><strong>Improving diagnostic clarity:<\/strong> Hyperreflexia is one piece of the puzzle that is considered alongside symptoms, strength testing, sensation, coordination, and imaging.<\/li>\n<\/ul>\n\n\n\n<p>The main \u201cbenefit\u201d is better clinical decision-making\u2014helping guide what to evaluate next and how urgently, rather than providing direct symptom relief.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Indications (When spine specialists use it)<\/h2>\n\n\n\n<p>Spine specialists and neurologically trained clinicians commonly assess for Hyperreflexia in scenarios such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Neck pain with <strong>hand numbness<\/strong>, loss of dexterity, or dropping objects<\/li>\n<li><strong>Gait imbalance<\/strong>, leg stiffness, or frequent tripping without a clear orthopedic cause<\/li>\n<li>Suspected <strong>cervical myelopathy<\/strong> (spinal cord dysfunction from neck pathology)<\/li>\n<li>Known or suspected <strong>spinal stenosis<\/strong>, especially when symptoms include coordination or walking changes<\/li>\n<li>Evaluation of <strong>radiculopathy vs myelopathy<\/strong> (nerve root irritation vs spinal cord involvement)<\/li>\n<li>Follow-up after spine injury, surgery, or progressive degenerative disease to document neurological status<\/li>\n<li>Workup of broader neurological concerns (for example, possible brain\/spinal cord pathway disorders), often in coordination with neurology<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Contraindications \/ when it\u2019s NOT ideal<\/h2>\n\n\n\n<p>Testing for reflexes is generally low risk, but Hyperreflexia is <strong>not always a reliable or specific indicator<\/strong> of a spine problem. Situations where it may be less suitable to rely on Hyperreflexia alone, or where interpretation may be limited, include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Acute pain or guarding<\/strong> that makes the patient tense, which can amplify reflexes<\/li>\n<li><strong>Anxiety, startle response, or inability to relax<\/strong>, which can increase reflex briskness<\/li>\n<li><strong>Medication effects<\/strong> (some drugs can change reflex responses); effects vary by medication and patient<\/li>\n<li><strong>Metabolic or systemic conditions<\/strong> (for example, thyroid abnormalities) that can alter neuromuscular excitability<\/li>\n<li><strong>Recent strenuous activity<\/strong> or stimulants that may temporarily heighten responses<\/li>\n<li><strong>Musculoskeletal limitations<\/strong> (severe arthritis, recent joint surgery, or significant swelling) that prevent proper positioning for reflex testing<\/li>\n<li><strong>Mixed neurological pictures<\/strong> (for example, combined spinal cord and peripheral nerve disease), where reflexes can be misleading<\/li>\n<\/ul>\n\n\n\n<p>In these cases, clinicians typically put more weight on the full neurological exam, functional findings (like walking), and confirmatory diagnostics (such as MRI), rather than Hyperreflexia in isolation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How it works (Mechanism \/ physiology)<\/h2>\n\n\n\n<p>Hyperreflexia reflects how reflex circuits are regulated by the nervous system.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Mechanism of action (physiology)<\/h3>\n\n\n\n<p>A <strong>deep tendon reflex (DTR)<\/strong>\u2014like the knee-jerk\u2014works through a fast pathway:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>A tendon tap stretches a muscle spindle (a stretch sensor in muscle).<\/li>\n<li>Sensory fibers carry the signal into the spinal cord.<\/li>\n<li>The spinal cord activates motor neurons that cause the muscle to contract.<\/li>\n<\/ol>\n\n\n\n<p>This circuit is normally <strong>modulated by descending pathways<\/strong> from the brain and brainstem that help \u201ctune\u201d the reflex. Many upper pathways provide <strong>inhibitory control<\/strong>, preventing reflexes from being excessively brisk.<\/p>\n\n\n\n<p>Hyperreflexia often occurs when those descending controls are disrupted, such as in <strong>upper motor neuron (UMN) involvement<\/strong> affecting the spinal cord or brain. With less inhibition, reflex responses can become exaggerated and may be associated with other UMN signs.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">Relevant spine anatomy and tissues<\/h3>\n\n\n\n<p>In a spine-focused context, the key structures include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Spinal cord:<\/strong> Runs through the spinal canal; carries descending motor control and ascending sensory signals.<\/li>\n<li><strong>Vertebrae and spinal canal:<\/strong> Degenerative changes, bone overgrowth, or alignment issues can reduce canal space.<\/li>\n<li><strong>Intervertebral discs:<\/strong> Disc bulges or herniations can contribute to canal narrowing or cord contact in some cases.<\/li>\n<li><strong>Ligaments (e.g., ligamentum flavum):<\/strong> Thickening can narrow the canal over time.<\/li>\n<li><strong>Facet joints:<\/strong> Arthritic enlargement can contribute to stenosis.<\/li>\n<li><strong>Nerve roots vs spinal cord:<\/strong> Nerve root problems more often reduce reflexes at a specific level, while spinal cord pathway issues can increase reflexes below the level of involvement (patterns vary by clinician and case).<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Onset, duration, and reversibility<\/h3>\n\n\n\n<p>Hyperreflexia is a <strong>finding<\/strong>, not a therapy, so typical \u201conset and duration\u201d in the treatment sense does not apply. Its presence can be:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Transient<\/strong>, influenced by stress, pain, or temporary physiological factors<\/li>\n<li><strong>Persistent<\/strong>, when related to ongoing nervous system pathway dysfunction<\/li>\n<\/ul>\n\n\n\n<p>Whether it improves depends on the underlying cause and how that cause evolves or is treated. This varies by clinician and case.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Hyperreflexia Procedure overview (How it\u2019s applied)<\/h2>\n\n\n\n<p>Because Hyperreflexia is not a procedure, the \u201capplication\u201d is best understood as <strong>how clinicians assess and interpret it<\/strong> within a neurological and spine evaluation.<\/p>\n\n\n\n<p>A typical high-level workflow is:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\n<p><strong>Evaluation \/ history<\/strong>\n   &#8211; Review symptoms such as neck\/back pain, numbness, weakness, balance issues, fine-motor difficulty, and changes in walking.\n   &#8211; Clarify symptom timing, progression, injuries, and relevant medical conditions.<\/p>\n<\/li>\n<li>\n<p><strong>Physical and neurological exam<\/strong>\n   &#8211; Test <strong>deep tendon reflexes<\/strong> (commonly biceps, brachioradialis, triceps, patellar, Achilles).\n   &#8211; Look for related findings such as <strong>clonus<\/strong> (rhythmic beats), asymmetry between sides, and reflex spread to nearby muscles.\n   &#8211; Assess strength, sensation, coordination, gait, and other upper motor neuron signs (for example, clinician-selected tests like Hoffmann or Babinski).<\/p>\n<\/li>\n<li>\n<p><strong>Imaging \/ diagnostics (when indicated)<\/strong>\n   &#8211; <strong>MRI<\/strong> is commonly used to evaluate spinal cord and soft tissues when myelopathy or significant stenosis is suspected.\n   &#8211; <strong>CT<\/strong> may help assess bony narrowing or alignment.\n   &#8211; <strong>Electrodiagnostic studies<\/strong> (EMG\/NCS) may be used when clinicians are differentiating peripheral nerve or nerve root disorders from spinal cord-related patterns; use varies by clinician and case.\n   &#8211; Bloodwork may be considered if systemic contributors are suspected; selection varies.<\/p>\n<\/li>\n<li>\n<p><strong>Interpretation and immediate checks<\/strong>\n   &#8211; Clinicians integrate reflex findings with the full exam and imaging, rather than treating Hyperreflexia as a standalone diagnosis.\n   &#8211; Severity and urgency are judged by the overall neurological picture.<\/p>\n<\/li>\n<li>\n<p><strong>Follow-up \/ monitoring<\/strong>\n   &#8211; Repeat exams may be performed over time to document stability or progression.\n   &#8211; Follow-up frequency and next steps vary by clinician and case.<\/p>\n<\/li>\n<\/ol>\n\n\n\n<h2 class=\"wp-block-heading\">Types \/ variations<\/h2>\n\n\n\n<p>Hyperreflexia can be described in several clinically relevant ways.<\/p>\n\n\n\n<h3 class=\"wp-block-heading\">By distribution<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Generalized Hyperreflexia:<\/strong> Brisk reflexes across multiple limbs, sometimes suggesting systemic, medication-related, or more widespread nervous system influences (interpretation varies).<\/li>\n<li><strong>Focal or regional Hyperreflexia:<\/strong> Briskness more prominent in one limb or one side, which may help with localization when combined with other exam findings.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">By severity and associated phenomena<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Brisk reflexes (increased DTRs):<\/strong> Stronger-than-expected response to a standard tendon tap.<\/li>\n<li><strong>Clonus:<\/strong> A series of rhythmic contractions, often tested at the ankle; sustained clonus is commonly considered a stronger upper motor neuron sign than simply brisk DTRs.<\/li>\n<li><strong>Reflex spread:<\/strong> Tapping one tendon triggers responses in nearby muscle groups, reflecting increased excitability.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">By neuroanatomical pattern (conceptual categories)<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Upper motor neuron pattern:<\/strong> Hyperreflexia with other UMN-associated findings (for example, increased tone\/spasticity, coordination changes, certain pathological reflexes), potentially pointing toward brain or spinal cord pathway involvement.<\/li>\n<li><strong>Mixed patterns:<\/strong> Some patients have both peripheral nerve\/nerve root problems and spinal cord pathway findings, complicating interpretation.<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">By spinal region relevance<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Cervical spine relevance:<\/strong> Because the spinal cord runs through the neck and supplies pathways to the arms and legs, cervical cord involvement can produce Hyperreflexia in the legs and sometimes the arms.<\/li>\n<li><strong>Thoracic spine relevance:<\/strong> Thoracic cord issues can affect trunk\/legs; arm reflexes may be normal.<\/li>\n<li><strong>Lumbar spine relevance:<\/strong> The adult spinal cord typically ends above the lumbar spine levels; lumbar problems often affect nerve roots rather than the cord, so reflex changes may differ (often reduced at a specific level), though overall interpretation varies by clinician and case.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Pros and cons<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\">Pros<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Helps <strong>screen<\/strong> for possible upper motor neuron involvement during a routine exam<\/li>\n<li>Can support <strong>localization<\/strong> when paired with strength, sensation, gait, and coordination findings<\/li>\n<li>Quick to assess and typically <strong>noninvasive<\/strong><\/li>\n<li>Useful for <strong>baseline documentation<\/strong> and follow-up comparisons over time<\/li>\n<li>Can raise suspicion for <strong>spinal cord-related conditions<\/strong> that may not present as classic \u201cpain-only\u201d problems<\/li>\n<li>Encourages a <strong>systems-based view<\/strong> (not all symptoms are purely musculoskeletal)<\/li>\n<\/ul>\n\n\n\n<h3 class=\"wp-block-heading\">Cons<\/h3>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Not specific:<\/strong> Hyperreflexia can occur for reasons unrelated to the spine<\/li>\n<li><strong>Exam-dependent:<\/strong> Technique, patient relaxation, and clinician experience can affect findings<\/li>\n<li><strong>Variable normal:<\/strong> Some people naturally have brisk reflexes without pathology<\/li>\n<li>May be <strong>masked or altered<\/strong> by medications, pain, fatigue, or concurrent peripheral nerve disease<\/li>\n<li>Does not reveal the cause by itself; usually requires <strong>correlation with imaging and other tests<\/strong><\/li>\n<li>Can create confusion if interpreted without the broader neurological context<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Aftercare &amp; longevity<\/h2>\n\n\n\n<p>Since Hyperreflexia is a clinical sign rather than a treatment, \u201caftercare\u201d focuses on what typically happens <strong>after it is identified<\/strong> and what influences how long it persists.<\/p>\n\n\n\n<p>Key factors that affect outcomes and how findings evolve include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Underlying cause and severity:<\/strong> For example, mild spinal cord irritation versus significant compression can present differently and change at different rates.<\/li>\n<li><strong>Progression over time:<\/strong> Some conditions are stable, while others may worsen; this varies by clinician and case.<\/li>\n<li><strong>Follow-up and reassessment:<\/strong> Repeat neurological exams and imaging decisions are often guided by symptom course and overall findings.<\/li>\n<li><strong>Rehabilitation participation (when used):<\/strong> Physical therapy or neuro-rehab may be part of a broader plan for function, balance, and strength depending on diagnosis; approaches vary.<\/li>\n<li><strong>General health factors:<\/strong> Bone quality, inflammatory conditions, diabetes, thyroid disease, and medication profiles can influence the broader neuromuscular picture.<\/li>\n<li><strong>If surgery or other interventions occur:<\/strong> Post-intervention neurological recovery patterns depend on diagnosis, timing, and individual factors. Hyperreflexia may persist even when other functions improve, or it may lessen; outcomes vary by clinician and case.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Alternatives \/ comparisons<\/h2>\n\n\n\n<p>Hyperreflexia is one data point. Clinicians often compare it with other approaches to understanding the nervous system and spine-related symptoms.<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Observation\/monitoring:<\/strong> In some scenarios\u2014especially when symptoms are mild and function is stable\u2014clinicians may monitor neurological status over time. Monitoring relies on changes in symptoms, function (like walking), and repeated exams; the appropriateness varies by clinician and case.<\/li>\n<li><strong>Symptom-focused conservative care (medications and physical therapy):<\/strong> These may help pain, mobility, and function in many spine conditions, but they do not directly \u201ctreat Hyperreflexia.\u201d If Hyperreflexia reflects spinal cord pathway involvement, the priority is usually identifying the cause rather than only treating pain.<\/li>\n<li><strong>Injections:<\/strong> Epidural steroid injections may help some radicular pain patterns, but they are not designed to reverse upper motor neuron signs. Decisions depend on diagnosis and overall findings.<\/li>\n<li><strong>Bracing:<\/strong> Bracing can support certain injuries or instability patterns, but it does not diagnose the reason for Hyperreflexia and may or may not be relevant.<\/li>\n<li><strong>Surgery vs conservative approaches:<\/strong> When Hyperreflexia is part of a broader pattern suggesting clinically significant spinal cord compression (for example, cervical myelopathy), surgery may be considered to relieve pressure or stabilize the spine. Whether surgery is appropriate, and expected neurological change afterward, varies by clinician and case.<\/li>\n<li><strong>Other diagnostic comparisons:<\/strong> Imaging (MRI\/CT), electrodiagnostics (EMG\/NCS), and laboratory studies can sometimes provide clearer evidence of cause than reflex testing alone, but each tool answers different questions and has limitations.<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Hyperreflexia Common questions (FAQ)<\/h2>\n\n\n\n<p><strong>Q: Does Hyperreflexia mean I have a serious spine problem?<\/strong><br\/>\nNot necessarily. Some people have naturally brisk reflexes, and reflexes can be influenced by stress, pain, or medications. Clinicians interpret Hyperreflexia alongside symptoms, strength, sensation, gait, and (when needed) imaging to understand whether it points to a spine or nervous system condition.<\/p>\n\n\n\n<p><strong>Q: Is Hyperreflexia painful to test?<\/strong><br\/>\nReflex testing is usually not painful, though the tendon tap can feel surprising. If a joint is already sore or inflamed, positioning and tapping may feel uncomfortable, and clinicians may adjust the exam.<\/p>\n\n\n\n<p><strong>Q: Does Hyperreflexia always indicate spinal cord compression?<\/strong><br\/>\nNo. Hyperreflexia can be seen with upper motor neuron pathway involvement, but it is not specific to spinal cord compression and can appear in other neurological or systemic contexts. Imaging and the rest of the neurological exam help determine the cause.<\/p>\n\n\n\n<p><strong>Q: Do I need anesthesia or a procedure to evaluate Hyperreflexia?<\/strong><br\/>\nNo. Hyperreflexia is identified during a standard office neurological exam without anesthesia. Additional tests, such as MRI or EMG, are separate diagnostic procedures that may or may not be recommended depending on the overall picture.<\/p>\n\n\n\n<p><strong>Q: How long does Hyperreflexia last once it appears?<\/strong><br\/>\nIt depends on the underlying cause. If it is related to temporary factors (like anxiety during the exam), it may not persist. If it reflects an ongoing neurological pathway issue, it may remain stable, progress, or partially improve depending on diagnosis and treatment; this varies by clinician and case.<\/p>\n\n\n\n<p><strong>Q: Is Hyperreflexia considered \u201csafe\u201d to have?<\/strong><br\/>\nHyperreflexia itself is not an action or exposure, so \u201csafety\u201d depends on what is causing it and whether there are associated functional problems. Clinicians focus on whether it comes with other neurological changes such as weakness, balance issues, or bowel\/bladder symptoms, which may warrant prompt evaluation.<\/p>\n\n\n\n<p><strong>Q: Can Hyperreflexia affect driving?<\/strong><br\/>\nReflex findings alone do not determine driving ability. Driving decisions usually depend on practical function\u2014strength, coordination, reaction control, sensation, and whether symptoms interfere with safe operation of a vehicle. If a condition causes leg stiffness, spasms, or gait instability, clinicians may discuss safety considerations in context.<\/p>\n\n\n\n<p><strong>Q: Can I keep working or exercising if Hyperreflexia is found?<\/strong><br\/>\nWork and activity decisions depend on your symptoms, functional status, and the suspected diagnosis. Some people with brisk reflexes have no limitations, while others may have balance or coordination issues that affect certain tasks. Clinicians typically base recommendations on the whole clinical picture, not reflexes alone.<\/p>\n\n\n\n<p><strong>Q: What does Hyperreflexia look like in cervical myelopathy?<\/strong><br\/>\nCervical myelopathy is spinal cord dysfunction from a neck-related cause. Hyperreflexia may appear in the legs and sometimes the arms, often alongside signs such as gait imbalance, hand clumsiness, or changes in strength and coordination. The exact pattern varies by clinician and case.<\/p>\n\n\n\n<p><strong>Q: Does Hyperreflexia change the cost of care?<\/strong><br\/>\nA reflex exam is usually part of a standard visit and does not add separate cost by itself. Costs are more affected by what happens next\u2014such as imaging, electrodiagnostic tests, therapy, or procedures\u2014based on the clinician\u2019s assessment and the care setting.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hyperreflexia means reflexes that are stronger or more easily triggered than expected. It is a clinical finding noticed during a neurological exam. It most often comes up when clinicians evaluate the brain, spinal cord, and nerve pathways. In spine care, it can be a clue to spinal cord involvement, especially in the neck.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-3158","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Hyperreflexia: Definition, Uses, and Clinical Overview - Best Spine Hospitals<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bestspinehospitals.com\/blog\/hyperreflexia-definition-uses-and-clinical-overview\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Hyperreflexia: Definition, Uses, and Clinical Overview - Best Spine Hospitals\" \/>\n<meta property=\"og:description\" content=\"Hyperreflexia means reflexes that are stronger or more easily triggered than expected. It is a clinical finding noticed during a neurological exam. It most often comes up when clinicians evaluate the brain, spinal cord, and nerve pathways. 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