{"id":2820,"date":"2026-02-27T19:13:17","date_gmt":"2026-02-27T19:13:17","guid":{"rendered":"https:\/\/www.bestspinehospitals.com\/blog\/microvascular-angina-definition-uses-and-clinical-overview\/"},"modified":"2026-02-27T19:13:17","modified_gmt":"2026-02-27T19:13:17","slug":"microvascular-angina-definition-uses-and-clinical-overview","status":"publish","type":"post","link":"https:\/\/www.bestspinehospitals.com\/blog\/microvascular-angina-definition-uses-and-clinical-overview\/","title":{"rendered":"Microvascular Angina: Definition, Uses, and Clinical Overview"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\">Microvascular Angina Introduction (What it is)<\/h2>\n\n\n\n<p>Microvascular Angina is chest discomfort or related symptoms caused by problems in the heart\u2019s smallest blood vessels.<br\/>\nIt can occur even when major coronary arteries look normal or only mildly narrowed on angiography.<br\/>\nIt is commonly discussed in cardiology clinics when people have angina-like symptoms but no clearly \u201cblocked\u201d arteries.<br\/>\nIt is also used in cardiovascular training to describe coronary microvascular dysfunction as a cause of ischemia.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why Microvascular Angina used (Purpose \/ benefits)<\/h2>\n\n\n\n<p>Microvascular Angina is used as a clinical concept to explain and organize care for people who have symptoms suggestive of reduced blood flow to the heart muscle (ischemia) without obstructive coronary artery disease in the large (epicardial) coronary arteries. In everyday terms, it addresses a gap: many patients have typical angina symptoms, yet standard angiograms do not show a major blockage that would fully explain the symptoms.<\/p>\n\n\n\n<p>Key purposes and potential benefits of using the Microvascular Angina framework include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Improving diagnostic accuracy for chest pain<\/strong>: It helps clinicians consider coronary microvascular dysfunction rather than concluding symptoms are \u201cnon-cardiac\u201d solely because major arteries are not severely narrowed.<\/li>\n<li><strong>Clarifying the mechanism of ischemia<\/strong>: It shifts attention to the small vessels that regulate blood flow within the heart muscle, including their ability to dilate (widen) appropriately during stress.<\/li>\n<li><strong>Guiding risk stratification and follow-up<\/strong>: Identifying microvascular disease can influence how clinicians interpret symptoms, test results, and overall cardiovascular risk in context.<\/li>\n<li><strong>Supporting targeted symptom evaluation<\/strong>: It encourages use of testing strategies that can detect ischemia or impaired coronary flow reserve when routine tests are non-diagnostic or conflicting.<\/li>\n<li><strong>Creating a shared language for patients and clinicians<\/strong>: A defined diagnosis can improve communication, reduce uncertainty, and structure longitudinal care planning.<\/li>\n<\/ul>\n\n\n\n<p>Microvascular Angina is not \u201cjust chest pain with a normal angiogram.\u201d It refers to a recognized pattern in which myocardial ischemia can arise from abnormal function and\/or structure of the coronary microcirculation.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Clinical context (When cardiologists or cardiovascular clinicians use it)<\/h2>\n\n\n\n<p>Microvascular Angina is typically considered or discussed in scenarios such as:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Angina-like chest discomfort with <strong>no obstructive coronary artery disease<\/strong> on coronary angiography or CT coronary angiography  <\/li>\n<li>Abnormal stress testing (suggesting ischemia) with <strong>angiography showing non-obstructive disease<\/strong><\/li>\n<li>Persistent exertional symptoms after a prior evaluation that did not identify a flow-limiting epicardial stenosis<\/li>\n<li>Symptoms occurring in association with conditions linked to microvascular dysfunction (for example, cardiometabolic risk factors), where macrovascular disease does not fully explain findings<\/li>\n<li>Evaluation of <strong>ischemia with non-obstructive coronary arteries (INOCA)<\/strong>, a broader clinical category in which Microvascular Angina is one potential mechanism<\/li>\n<li>Consideration alongside <strong>vasospastic angina<\/strong> (epicardial coronary spasm) when symptoms suggest coronary spasm physiology and testing is needed to differentiate mechanisms<\/li>\n<li>Chest pain syndromes in which clinicians are also assessing non-cardiac contributors (gastroesophageal, musculoskeletal, pulmonary, anxiety-related), but cardiac ischemia remains on the differential diagnosis<\/li>\n<\/ul>\n\n\n\n<p>In practice, Microvascular Angina is referenced when clinicians assess coronary blood flow regulation, coronary flow reserve, microvascular resistance, and\/or endothelial function.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Contraindications \/ when it\u2019s NOT ideal<\/h2>\n\n\n\n<p>Because Microvascular Angina is a diagnosis and clinical framework (not a single procedure), \u201ccontraindications\u201d mainly refer to situations where the label is not appropriate, or where other diagnoses and pathways take priority.<\/p>\n\n\n\n<p>Microvascular Angina is generally <strong>not the preferred explanation<\/strong> when:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>There is <strong>clear obstructive coronary artery disease<\/strong> that plausibly explains ischemia (a major epicardial stenosis causing supply\u2013demand mismatch)<\/li>\n<li>Findings and symptoms are more consistent with <strong>acute coronary syndrome<\/strong> (a time-sensitive condition requiring an urgent diagnostic pathway), rather than a stable microvascular syndrome<\/li>\n<li>The presentation suggests <strong>non-ischemic<\/strong> cardiac causes of chest symptoms, such as pericarditis, significant valvular disease, or certain cardiomyopathies, where the mechanism is not primarily microvascular angina<\/li>\n<li>Symptoms are better explained by <strong>non-cardiac<\/strong> etiologies after appropriate evaluation (for example, pulmonary or gastrointestinal causes), and ischemia testing does not support a cardiac mechanism<\/li>\n<li>There is a primary rhythm problem (arrhythmia) driving symptoms like palpitations and lightheadedness without evidence of ischemia<\/li>\n<li>Another specific coronary functional disorder is identified as dominant, such as <strong>epicardial coronary spasm<\/strong> without microvascular involvement (recognizing that overlap can occur)<\/li>\n<\/ul>\n\n\n\n<p>When the mechanism is uncertain, clinicians may use broader terms (such as INOCA) until testing clarifies whether microvascular dysfunction, epicardial spasm, both, or neither are present.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">How it works (Mechanism \/ physiology)<\/h2>\n\n\n\n<p>Microvascular Angina centers on dysfunction of the <strong>coronary microcirculation<\/strong>\u2014the network of small arteries and arterioles within the heart muscle that cannot be directly visualized well on standard coronary angiography. These vessels play a critical role in matching oxygen supply to the myocardium (heart muscle) as demand changes with exercise, stress, or illness.<\/p>\n\n\n\n<p>High-level mechanisms commonly discussed include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Impaired vasodilation (reduced ability to widen):<\/strong> During exertion or stress, healthy microvessels dilate to increase blood flow. If dilation is blunted, the myocardium may not receive adequate oxygen, producing ischemia and angina symptoms.<\/li>\n<li><strong>Endothelial dysfunction:<\/strong> The endothelium (inner lining of blood vessels) helps regulate vascular tone and blood flow. Dysfunction can shift vessels toward constriction, inflammation, and abnormal flow responses.<\/li>\n<li><strong>Increased microvascular resistance:<\/strong> Structural remodeling, rarefaction (reduced microvessel density), or functional constriction can raise resistance to blood flow in the small vessels.<\/li>\n<li><strong>Microvascular spasm:<\/strong> Some patients may have inappropriate constriction of the microvasculature, causing transient ischemia.<\/li>\n<li><strong>Supply\u2013demand mismatch without large-vessel obstruction:<\/strong> Even when large coronary arteries are not severely narrowed, microvascular dysfunction can limit perfusion during increased demand.<\/li>\n<\/ul>\n\n\n\n<p>Relevant anatomy and physiology in simple terms:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>The <strong>epicardial coronary arteries<\/strong> are the larger surface vessels often evaluated for blockages on angiography.<\/li>\n<li>The <strong>microvasculature<\/strong> (small intramyocardial vessels) governs fine control of blood delivery to the heart muscle.<\/li>\n<li><strong>Ischemia<\/strong> refers to inadequate oxygen delivery relative to myocardial demand; it can be transient and reversible, but persistent or severe ischemia can be clinically significant.<\/li>\n<\/ul>\n\n\n\n<p>Clinical interpretation often emphasizes that Microvascular Angina can produce symptoms and ischemia patterns that resemble obstructive coronary disease, yet standard \u201cblockage-focused\u201d testing may not capture the underlying functional problem.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Microvascular Angina Procedure overview (How it\u2019s applied)<\/h2>\n\n\n\n<p>Microvascular Angina is not a single procedure. It is evaluated through a structured clinical workflow that combines symptom assessment with testing aimed at ischemia and coronary function.<\/p>\n\n\n\n<p>A typical high-level workflow may include:<\/p>\n\n\n\n<ol class=\"wp-block-list\">\n<li>\n<p><strong>Evaluation \/ exam<\/strong>\n   &#8211; Symptom review (character, triggers, duration, associated shortness of breath, fatigue)\n   &#8211; Cardiovascular risk factor assessment and medical history\n   &#8211; Physical examination and baseline tests such as ECG and routine labs as clinically indicated<\/p>\n<\/li>\n<li>\n<p><strong>Preparation (context setting for testing)<\/strong>\n   &#8211; Selecting an initial strategy: noninvasive ischemia testing, anatomic imaging, or invasive evaluation depending on the clinical scenario\n   &#8211; Reviewing medications and factors that can influence test interpretation (varies by clinician and case)<\/p>\n<\/li>\n<li>\n<p><strong>Intervention \/ testing<\/strong>\n   &#8211; <strong>Noninvasive testing<\/strong> may include exercise or pharmacologic stress testing with ECG, echocardiography, nuclear perfusion imaging, PET, or stress cardiac MRI, depending on local expertise and availability.\n   &#8211; <strong>Anatomic assessment<\/strong> may use CT coronary angiography or invasive coronary angiography to assess epicardial coronary disease.\n   &#8211; <strong>Coronary function testing (invasive in some centers)<\/strong> can assess coronary flow reserve, microvascular resistance indices, and responses to vasoactive agents to evaluate microvascular dysfunction and\/or coronary spasm.<\/p>\n<\/li>\n<li>\n<p><strong>Immediate checks<\/strong>\n   &#8211; Interpreting results in clinical context: whether findings support ischemia, whether epicardial disease explains symptoms, and whether functional coronary disorders are likely<\/p>\n<\/li>\n<li>\n<p><strong>Follow-up<\/strong>\n   &#8211; Ongoing symptom assessment and risk-factor management discussions\n   &#8211; Periodic reassessment if symptoms change, if new signs appear, or if test findings warrant longitudinal monitoring (varies by clinician and case)<\/p>\n<\/li>\n<\/ol>\n\n\n\n<p>Because practice patterns differ, the exact sequence and test selection can vary by clinician and case.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Types \/ variations<\/h2>\n\n\n\n<p>Microvascular Angina is discussed with several overlapping classifications. Common variations include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Microvascular Angina within INOCA:<\/strong> A mechanism-specific subset of ischemia with non-obstructive coronary arteries where microvascular dysfunction is identified or strongly suspected.<\/li>\n<li><strong>Functional vs structural microvascular dysfunction<\/strong><\/li>\n<li><em>Functional:<\/em> abnormal vasomotor responses (impaired dilation or inappropriate constriction)<\/li>\n<li><em>Structural:<\/em> remodeling or changes that increase resistance and reduce perfusion reserve<\/li>\n<li><strong>Microvascular Angina with or without vasospasm overlap<\/strong><\/li>\n<li>Some patients have microvascular dysfunction alone.<\/li>\n<li>Others may have combined microvascular dysfunction and epicardial or microvascular spasm, depending on testing and clinical features.<\/li>\n<li><strong>Stable (chronic) symptom patterns vs episodic presentations<\/strong><\/li>\n<li>Symptoms may be exertional and reproducible, or intermittent and variable.<\/li>\n<li><strong>Primary vs secondary context<\/strong><\/li>\n<li><em>Primary:<\/em> microvascular dysfunction as the main identified mechanism<\/li>\n<li><em>Secondary:<\/em> microvascular dysfunction occurring alongside other cardiac conditions (for example, hypertensive heart changes or cardiomyopathy), where ischemia physiology can be multifactorial<\/li>\n<\/ul>\n\n\n\n<p>These categories are not always mutually exclusive, and terminology may differ across institutions and clinicians.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Pros and cons<\/h2>\n\n\n\n<p>Pros:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Helps explain angina-like symptoms when major coronary arteries are not severely blocked  <\/li>\n<li>Encourages a more complete evaluation of ischemia beyond \u201cblockage-only\u201d thinking  <\/li>\n<li>Supports use of functional testing (coronary flow reserve, microvascular resistance) when appropriate  <\/li>\n<li>Can improve diagnostic clarity for patients with persistent symptoms and nondiagnostic standard evaluations  <\/li>\n<li>Frames symptoms within coronary physiology, which can guide structured follow-up and monitoring  <\/li>\n<li>Highlights that ischemia can occur in multiple coronary compartments (large and small vessels)<\/li>\n<\/ul>\n\n\n\n<p>Cons:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Diagnosis can be challenging because the microvasculature is not directly visualized on standard angiography  <\/li>\n<li>Terminology overlaps with INOCA and vasospastic angina, which can cause confusion without careful definitions  <\/li>\n<li>Testing approaches are not uniform across healthcare systems and may depend on local expertise and availability  <\/li>\n<li>Symptoms can overlap with non-cardiac chest pain syndromes, complicating interpretation  <\/li>\n<li>Results may be nuanced (not simply \u201cpositive\u201d or \u201cnegative\u201d), requiring careful clinical correlation  <\/li>\n<li>Some patients may have mixed mechanisms (microvascular dysfunction plus mild epicardial disease), making single-label explanations less tidy<\/li>\n<\/ul>\n\n\n\n<h2 class=\"wp-block-heading\">Aftercare &amp; longevity<\/h2>\n\n\n\n<p>Aftercare for Microvascular Angina generally refers to ongoing monitoring, symptom reassessment, and cardiovascular risk management within a long-term care plan. Because Microvascular Angina is often a chronic syndrome with variable symptom patterns, \u201clongevity\u201d typically means the durability of symptom control and the stability of cardiovascular status over time rather than a one-time cure.<\/p>\n\n\n\n<p>Factors that can influence outcomes in general include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Severity and dominant mechanism<\/strong> (for example, impaired flow reserve vs spasm physiology, or mixed mechanisms)<\/li>\n<li><strong>Cardiometabolic risk factors<\/strong> (blood pressure, lipids, glucose regulation, body weight, sleep health), which can affect endothelial and microvascular function<\/li>\n<li><strong>Coexisting conditions<\/strong> such as heart failure with preserved ejection fraction (HFpEF), cardiomyopathies, anemia, or chronic inflammatory conditions, which can shape symptoms and ischemia susceptibility<\/li>\n<li><strong>Medication tolerance and adherence<\/strong> as determined by clinician and patient, recognizing that response varies by clinician and case<\/li>\n<li><strong>Follow-up structure<\/strong> including reassessment when symptoms change, and periodic review of test results and risk profile<\/li>\n<li><strong>Rehabilitation and physical conditioning<\/strong> when incorporated into a broader cardiovascular care plan, as appropriate to the individual situation (varies by clinician and case)<\/li>\n<\/ul>\n\n\n\n<p>Some people experience fluctuating symptoms, while others have more consistent patterns; clinicians typically interpret symptom trajectories alongside objective findings and comorbidities.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Alternatives \/ comparisons<\/h2>\n\n\n\n<p>Microvascular Angina is best understood in comparison with other explanations for chest pain and ischemia, as well as alternative diagnostic strategies.<\/p>\n\n\n\n<p>Common comparisons include:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><strong>Obstructive coronary artery disease (CAD) vs Microvascular Angina<\/strong><\/li>\n<li><em>Obstructive CAD:<\/em> flow limitation from a significant narrowing in a major coronary artery; angiography often identifies a target lesion.<\/li>\n<li>\n<p><em>Microvascular Angina:<\/em> impaired regulation of blood flow at the small-vessel level; angiography may show non-obstructive disease, requiring functional evaluation to support the diagnosis.<\/p>\n<\/li>\n<li>\n<p><strong>Vasospastic angina vs Microvascular Angina<\/strong><\/p>\n<\/li>\n<li><em>Vasospastic angina:<\/em> transient constriction of an epicardial coronary artery causing ischemia; symptoms may occur at rest and can be episodic.<\/li>\n<li>\n<p><em>Microvascular Angina:<\/em> dysfunction or spasm in the microvasculature; overlap can occur, and specialized testing may be used to differentiate.<\/p>\n<\/li>\n<li>\n<p><strong>Noninvasive vs invasive testing<\/strong><\/p>\n<\/li>\n<li><em>Noninvasive:<\/em> stress echo, nuclear imaging, PET, or stress cardiac MRI can demonstrate ischemia patterns and sometimes quantify flow.<\/li>\n<li>\n<p><em>Invasive coronary function testing:<\/em> can directly assess physiologic indices (such as flow reserve and resistance) and vasoreactivity in a catheterization lab setting; availability varies by center.<\/p>\n<\/li>\n<li>\n<p><strong>Observation\/monitoring vs expanded evaluation<\/strong><\/p>\n<\/li>\n<li>Some cases are managed with symptom tracking and risk assessment after initial testing.<\/li>\n<li>\n<p>Other cases pursue more detailed coronary functional assessment when symptoms persist or when clarity is needed; the approach varies by clinician and case.<\/p>\n<\/li>\n<li>\n<p><strong>Non-cardiac chest pain evaluation<\/strong><\/p>\n<\/li>\n<li>Gastrointestinal, pulmonary, and musculoskeletal causes can mimic angina.<\/li>\n<li>Microvascular Angina remains a consideration when ischemia physiology is supported or strongly suspected despite non-obstructive epicardial arteries.<\/li>\n<\/ul>\n\n\n\n<p>These comparisons help clinicians avoid false reassurance from a \u201cnormal-looking angiogram\u201d while also avoiding over-attribution of symptoms to coronary causes when other diagnoses fit better.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Microvascular Angina Common questions (FAQ)<\/h2>\n\n\n\n<p><strong>Q: What does Microvascular Angina feel like?<\/strong><br\/>\nIt can feel similar to typical angina: chest pressure, tightness, heaviness, or discomfort. Some people notice shortness of breath, unusual fatigue, or reduced exercise tolerance instead of classic chest pain. Symptom patterns can vary and may not always match the \u201ctextbook\u201d description of angina.<\/p>\n\n\n\n<p><strong>Q: Can you have Microvascular Angina if your angiogram is normal?<\/strong><br\/>\nYes. A standard coronary angiogram is designed to evaluate the larger epicardial coronary arteries, not the small intramyocardial vessels. Microvascular dysfunction can be present even when no major blockage is seen.<\/p>\n\n\n\n<p><strong>Q: Is Microvascular Angina the same as INOCA?<\/strong><br\/>\nNot exactly. INOCA is a broader category meaning ischemia with non-obstructive coronary arteries, and Microvascular Angina is one mechanism within that category. Other mechanisms (such as vasospasm) can also fall under INOCA.<\/p>\n\n\n\n<p><strong>Q: How is Microvascular Angina diagnosed?<\/strong><br\/>\nDiagnosis typically combines symptom assessment with evidence of ischemia and evaluation showing that obstructive epicardial coronary disease does not explain the symptoms. Depending on the case, clinicians may use noninvasive stress testing, CT coronary angiography, invasive coronary angiography, and sometimes coronary function testing to assess microvascular physiology.<\/p>\n\n\n\n<p><strong>Q: Is it considered \u201csafe\u201d compared with blocked-artery angina?<\/strong><br\/>\nMicrovascular Angina is generally discussed as a real cardiac condition rather than a benign finding. Risk and prognosis depend on the individual\u2019s overall cardiovascular profile, test results, and comorbidities, so it is not described in one-size-fits-all terms.<\/p>\n\n\n\n<p><strong>Q: What treatments are used for Microvascular Angina?<\/strong><br\/>\nTreatment approaches vary by clinician and case and often focus on symptom control and cardiovascular risk-factor management. Options may include anti-anginal medications, medications that support vascular\/endothelial function, and structured lifestyle or rehabilitation strategies as part of a broader cardiovascular plan.<\/p>\n\n\n\n<p><strong>Q: Will I need to stay in the hospital for testing?<\/strong><br\/>\nMany evaluations (such as outpatient stress tests or CT coronary angiography) are commonly done without hospitalization. Invasive coronary angiography and coronary function testing are typically performed in a hospital or procedural center, often with same-day discharge depending on the situation and local protocols.<\/p>\n\n\n\n<p><strong>Q: How long do results last\u2014can Microvascular Angina go away?<\/strong><br\/>\nSymptoms may improve, fluctuate, or persist over time. Some contributors to microvascular dysfunction can change with risk-factor control and overall health status, but the course is individualized and varies by clinician and case.<\/p>\n\n\n\n<p><strong>Q: Does Microvascular Angina affect exercise and daily activity?<\/strong><br\/>\nMany people notice symptoms with exertion, but activity effects differ widely. Clinicians often interpret symptom patterns alongside objective testing and may suggest structured activity planning within a broader cardiovascular care approach, tailored to the individual context (varies by clinician and case).<\/p>\n\n\n\n<p><strong>Q: What does evaluation and treatment typically cost?<\/strong><br\/>\nCosts vary widely depending on country, insurance coverage, testing modality (noninvasive vs invasive), and care setting. In general, advanced imaging and invasive functional testing tend to be more resource-intensive than basic outpatient assessments. The most relevant estimate is usually obtained from the local healthcare system and the planned testing pathway.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Microvascular Angina is chest discomfort or related symptoms caused by problems in the heart\u2019s smallest blood vessels. It can occur even when major coronary arteries look normal or only mildly narrowed on angiography. It is commonly discussed in cardiology clinics when people have angina-like symptoms but no clearly \u201cblocked\u201d arteries. It is also used in cardiovascular training to describe coronary microvascular dysfunction as a cause of ischemia.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-2820","post","type-post","status-publish","format-standard","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v25.8 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Microvascular Angina: Definition, Uses, and Clinical Overview - Best Spine Hospitals<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.bestspinehospitals.com\/blog\/microvascular-angina-definition-uses-and-clinical-overview\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Microvascular Angina: Definition, Uses, and Clinical Overview - Best Spine Hospitals\" \/>\n<meta property=\"og:description\" content=\"Microvascular Angina is chest discomfort or related symptoms caused by problems in the heart\u2019s smallest blood vessels. It can occur even when major coronary arteries look normal or only mildly narrowed on angiography. It is commonly discussed in cardiology clinics when people have angina-like symptoms but no clearly \u201cblocked\u201d arteries. 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It can occur even when major coronary arteries look normal or only mildly narrowed on angiography. It is commonly discussed in cardiology clinics when people have angina-like symptoms but no clearly \u201cblocked\u201d arteries. 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